Vitamin C is a potent antioxidant that can be used topically in dermatology to treat and prevent changes associated with photoageing. It can also be used for the treatment of hyperpigmentation. Because it is unstable and difficult to deliver into the dermis in the optimum dosage, research is being directed to find stable compounds of Vitamin C and newer methods of delivery of Vitamin C into the dermis.
Topical formulation of vitamin C
Vitamin C is available in the market as a variety of creams, serum and transdermal patches. Of these, only the serum contains active Vitamin C in an almost colorless form. It is unstable and, on exposure to light, gets oxidized to Dehydro Ascorbic Acid (DHAA), which imparts a yellow color. The stability of Vitamin C is controlled by maintaining a pH of less than 3.5. At this pH, the ionic charge on the molecule is removed and it is transported well across the stratum corneum.
Antioxidants come in many forms such as Vitamin E, Vitamin A, plant stem cells and peptides, which all have potent antioxidant properties. Vitamin C is a highly effective antioxidant especially when paired with ferulic acid.